Depression, like just about every other mental disease, is a strange and mysterious beast. We’ve reached the stage where most people finally understand that it’s really an illness, really a physical problem, not something can be controlled. We know that there are myriad drugs that can help: citalopram, sertraline, paroxetine, fluoxetine… But we still can’t reach out and touch it. We still can’t predict it. There’s still not a physical test that you can do. An assay that proves that no, this person isn’t just lazy or melancholy or antisocial: they are depressed.
Over the weekend, the news outlets got a bit excited at the prospect that scientists had finally discovered “the molecule responsible for causing feelings of depression” (Independent), “the brain’s most miserable molecule” (The Sunday Times) “the little bastard molecule that causes depression” (msn), “The Thing Responsible for Depression” (Jezebel).
And the science
I wish I could say I’m as excited as they are, but of course the science is never as simple as this. The actual paper released is a slog to say the least, and more Physics than Biology, but I’ll give it a go. Continue reading