Tag Archives: disease

Crowd sourcing genetics: Ash die back on Facebook

Sometimes I am astounded by the sheer volume of data that we create in science nowadays. Where a few years ago we were sequencing individual genes, made up of a few thousand letters, now with a single Illumina run we can generate terabytes of data.

But what to do with that data? A lot of genomics at the moment is concerned with targeted resequencing, and bulk segregant analysis. Producing genome #1 is a lot of hard work, and doesn’t tell us all that much. Producing genomes #2 to #10 for the same species tells us a lot more: Why does wheat cultivar 1 have a higher yield than wheat cultivar 2? Why is apple variety 1 susceptible to a disease when apple variety 2 is not?  Continue reading

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1092 humans, 14 populations, 1 map.

A little while ago, I wrote a tiny bit about the  1000 genomes project, in which scientists hoped to sequenced the genomes of 1000 individuals and use them as a basis of comparison to pin down the genetic variation contributing to disease. About a week ago, the consortium published their findings, and somehow I missed it: shock horror. Continue reading